When their parish goes broke, Agatha and three other young Catholic sisters leave their beloved Mother Roberta and move to an old mill town to provide care at a halfway house dubbed "Little Neon." The residents there, along with Agatha's new teaching job at a local high school, begin to change her perception of the world in unexpected ways. Navigating a religious crisis and exploring the many meanings of sisterhood, Agatha of Little Neon offers a wry and heartfelt rumination on faith in humanity.